Bacterial flagellin—a potent immunomodulatory agent
نویسندگان
چکیده
منابع مشابه
Potent immunomodulatory effects of the trifunctional antibody catumaxomab.
Catumaxomab (CatmAb), a trifunctional bispecific antibody directed against the epithelial cell adhesion molecule (EpCAM) and the T-cell antigen CD3, is approved as intraperitoneal therapy for the treatment of malignant ascites in patients with EpCAM-positive carcinomas. The immunomonitoring results of a phase II/III study using CatmAb revealed a tumoricidal effect associated with reduced VEGF l...
متن کاملRole of Fructose as a Potent Antiarrhythmic and Anti-infarct agent in Isolated Rat Heart
In the current study, effects of acute short term administration of fructose on cardiac arrhythmias and myocardial infarction size following ischemia/reperfusion were investigated in isolated rat heart. The hearts were subjected to 30 min zero flow global ischemia followed by 120 min reperfusion. In the control group, the hearts were perfused by normal drug free Krebs-Henseleit (K/H) solution t...
متن کاملPeroxynitrite: a potent oxidizing and nitrating agent.
Nitric oxide (NO*) reacts with superoxide (O2-*) forming peroxynitrite (PXN) (ONOO-), a strong oxidant which reacts with several biomolecules leading to enormous implications in biological process, holds enormous implications for the understanding of free radicals. The ONOO- formation in vivo has significant implications in free radical biology. It exerts a defensive role in large number of pat...
متن کاملVinpocetine as a potent antiinflammatory agent.
C hronic inflammatory processes are related to conditions as distinct as atherosclerosis, amyotrophic lateral sclerosis, asthma, systemic lupus, Alzheimer’s disease, and Parkinson’s disease. The continuous use of antiinflammatory agents is required to treat these conditions. However, the longterm use of these drugs creates an additional challenge: the high frequency of severe side effects. For ...
متن کاملPotent Biological Agent Benzimidazole–a Review
Benzimidazole nucleus is one of the most important heterocycles exhibiting remarkable pharmacological activities. Numerous method for the synthesis of benzimidazole and also their diverse reactions offer enormous scope in the field of medicinal chemistry. Various reported biological activities (analgesic, anti-inflammatory, anthelmintic, anticancer, anthelmintic, antioxidant, antitubercular, an...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental & Molecular Medicine
سال: 2017
ISSN: 1226-3613,2092-6413
DOI: 10.1038/emm.2017.172